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  4. Recombinant Mouse C->U-editing enzyme APOBEC-2 (Apobec2)

Recombinant Mouse C->U-editing enzyme APOBEC-2 (Apobec2)

  • 中文名称：
    Recombinant Mouse C->U-editing enzyme APOBEC-2(Apobec2),Yeast
  • 货号：
    CSB-YP896254MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse C->U-editing enzyme APOBEC-2(Apobec2),Yeast
  • 货号：
    CSB-EP896254MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse C->U-editing enzyme APOBEC-2(Apobec2),Yeast
  • 货号：
    CSB-EP896254MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse C->U-editing enzyme APOBEC-2(Apobec2),Yeast
  • 货号：
    CSB-BP896254MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse C->U-editing enzyme APOBEC-2(Apobec2),Yeast
  • 货号：
    CSB-MP896254MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Apobec2
  • Uniprot No.：
  • 别名：
    Apobec2; C->U-editing enzyme APOBEC-2; EC 3.5.4.36; mRNA(cytosine(6666)) deaminase 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-224
  • 氨基酸序列
    MAQKEEAAEA AAPASQNGDD LENLEDPEKL KELIDLPPFE IVTGVRLPVN FFKFQFRNVE YSSGRNKTFL CYVVEVQSKG GQAQATQGYL EDEHAGAHAE EAFFNTILPA FDPALKYNVT WYVSSSPCAA CADRILKTLS KTKNLRLLIL VSRLFMWEEP EVQAALKKLK EAGCKLRIMK PQDFEYIWQN FVEQEEGESK AFEPWEDIQE NFLYYEEKLA DILK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
  • 基因功能参考文献：
    1. Apobec2 deficiency causes mitochondrial defects that increase muscle mitophagy, leading to myopathy and atrophy. Findings demonstrate that Apobec2 is required for mitochondrial homeostasis to maintain normal skeletal muscle function. PMID: 29127187
    2. gene-specific shRNA enhance DNA vaccine immunogenicity PMID: 25953029
    3. Hepatocellular carcinoma developed in 2 of 20 APOBEC2 transgenic mice at 72 weeks of age. PMID: 21469143
    4. Data show that APOBEC2 is preferentially associated with slow-twitch muscle, with its abundance being considerably greater in soleus compared with gastrocnemius muscle and, within soleus muscle, in slow as opposed to fast muscle fibers. PMID: 20022958
    5. both APOBEC2 (despite being an ancestral member of the family with no obvious redundancy in muscle) and APOBEC3 (despite its proposed role in restricting endogenous retrotransposition) are inessential for mouse development, survival, or fertility PMID: 16055735

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  • 蛋白家族：
    Cytidine and deoxycytidylate deaminase family
  • 组织特异性：
    Expressed exclusively in heart and skeletal muscle.
  • 数据库链接：

    KEGG: mmu:11811

    STRING: 10090.ENSMUSP00000047402

    UniGene: Mm.281793